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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
WEE1
All Species:
11.82
Human Site:
S165
Identified Species:
20
UniProt:
P30291
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.31
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P30291
NP_003381.1
646
71597
S165
R
A
G
E
G
R
R
S
P
R
P
D
H
P
G
Chimpanzee
Pan troglodytes
XP_521839
646
71607
S165
R
A
G
E
G
R
R
S
P
R
P
D
H
P
G
Rhesus Macaque
Macaca mulatta
NP_001099016
568
63102
L120
P
N
S
M
L
S
R
L
A
I
S
P
T
G
K
Dog
Lupus familis
XP_534051
887
95991
S406
R
A
S
E
G
P
C
S
P
L
P
D
H
P
G
Cat
Felis silvestris
Mouse
Mus musculus
P47810
646
71560
C164
P
R
A
M
D
D
P
C
S
P
Q
P
D
Y
P
Rat
Rattus norvegicus
Q63802
646
71478
S165
R
A
M
D
D
P
C
S
P
Q
P
D
Y
P
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510171
572
63943
R124
K
S
L
L
S
K
A
R
G
L
D
S
S
S
V
Chicken
Gallus gallus
NP_001026352
641
70947
L161
G
D
E
P
G
S
P
L
P
D
Y
P
G
T
P
Frog
Xenopus laevis
P47817
555
61670
K106
C
D
T
P
Y
T
P
K
S
L
L
Y
K
T
L
Zebra Danio
Brachydanio rerio
NP_001005770
612
68517
T152
R
K
L
R
L
F
D
T
P
H
T
P
K
S
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P54350
609
68790
L153
L
P
L
H
N
R
K
L
P
T
Q
D
T
A
N
Honey Bee
Apis mellifera
XP_624069
589
66032
K141
M
H
T
P
F
P
S
K
C
T
R
L
F
S
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999796
624
68925
R160
K
A
N
A
S
A
R
R
N
K
L
L
A
S
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8L4H0
500
56512
N52
L
S
K
I
S
F
E
N
R
P
S
S
N
V
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
42.1
70.9
N.A.
90.5
91.6
N.A.
72.7
80.1
42.8
64.2
N.A.
36.5
41.6
N.A.
39.6
Protein Similarity:
100
99.8
56.1
71.3
N.A.
92.7
93.1
N.A.
79.2
85.9
55.2
75
N.A.
54.1
59.2
N.A.
55.5
P-Site Identity:
100
100
6.6
73.3
N.A.
0
46.6
N.A.
0
13.3
0
13.3
N.A.
20
0
N.A.
13.3
P-Site Similarity:
100
100
6.6
73.3
N.A.
0
66.6
N.A.
20
13.3
0
20
N.A.
26.6
0
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
23
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.8
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
36
8
8
0
8
8
0
8
0
0
0
8
8
8
% A
% Cys:
8
0
0
0
0
0
15
8
8
0
0
0
0
0
0
% C
% Asp:
0
15
0
8
15
8
8
0
0
8
8
36
8
0
0
% D
% Glu:
0
0
8
22
0
0
8
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
8
15
0
0
0
0
0
0
8
0
0
% F
% Gly:
8
0
15
0
29
0
0
0
8
0
0
0
8
8
22
% G
% His:
0
8
0
8
0
0
0
0
0
8
0
0
22
0
0
% H
% Ile:
0
0
0
8
0
0
0
0
0
8
0
0
0
0
0
% I
% Lys:
15
8
8
0
0
8
8
15
0
8
0
0
15
0
8
% K
% Leu:
15
0
22
8
15
0
0
22
0
22
15
15
0
0
22
% L
% Met:
8
0
8
15
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
8
0
8
0
0
8
8
0
0
0
8
0
8
% N
% Pro:
15
8
0
22
0
22
22
0
50
15
29
29
0
29
15
% P
% Gln:
0
0
0
0
0
0
0
0
0
8
15
0
0
0
0
% Q
% Arg:
36
8
0
8
0
22
29
15
8
15
8
0
0
0
8
% R
% Ser:
0
15
15
0
22
15
8
29
15
0
15
15
8
29
8
% S
% Thr:
0
0
15
0
0
8
0
8
0
15
8
0
15
15
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
0
0
0
8
8
8
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _